|Other Names||Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific Expressed in the proximal tubule of the kidney (at protein level)|
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This gene is a member of the K-Cl cotransporter (KCC)family. K-Cl cotransporters are integral membrane proteins thatlower intracellular chloride concentrations below theelectrochemical equilibrium potential. The proteins encoded by thisgene are activated by cell swelling induced by hypotonicconditions. Alternate splicing results in multiple transcriptvariants encoding different isoforms. Mutations in this gene areassociated with agenesis of the corpus callosum with peripheralneuropathy.
Rinehart, J., et al. Cell 138(3):525-536(2009)Rudnik-Schoneborn, S., et al. Neuropediatrics 40(3):129-133(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Moser, D., et al. Neuropsychopharmacology 34(2):458-467(2009)Salin-Cantegrel, A., et al. Hum. Mol. Genet. 17(17):2703-2711(2008)
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