SLC12A6 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UHW9 |
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Clone Names | 100318242 |
Gene ID | 9990 |
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Other Names | Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC12A6 (HGNC:10914) |
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Function | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:11551954, PubMed:10600773, PubMed:19665974, PubMed:18566107, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q924N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q924N4} |
Tissue Location | Expressed in brain (at protein level) (PubMed:21628467). Highly expressed in heart, brain and kidney Detected at lower levels in skeletal muscle, placenta, lung and pancreas (PubMed:10600773). Detected in umbilical vein endothelial cells (PubMed:16048901). [Isoform 5]: Testis specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the K-Cl cotransporter (KCC)family. K-Cl cotransporters are integral membrane proteins thatlower intracellular chloride concentrations below theelectrochemical equilibrium potential. The proteins encoded by thisgene are activated by cell swelling induced by hypotonicconditions. Alternate splicing results in multiple transcriptvariants encoding different isoforms. Mutations in this gene areassociated with agenesis of the corpus callosum with peripheralneuropathy.
References
Rinehart, J., et al. Cell 138(3):525-536(2009)Rudnik-Schoneborn, S., et al. Neuropediatrics 40(3):129-133(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Moser, D., et al. Neuropsychopharmacology 34(2):458-467(2009)Salin-Cantegrel, A., et al. Hum. Mol. Genet. 17(17):2703-2711(2008)
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