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SLC12A6 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UHW9
Clone Names 100318242
Additional Information
Gene ID 9990
Other Names Solute carrier family 12 member 6, Electroneutral potassium-chloride cotransporter 3, K-Cl cotransporter 3, SLC12A6, KCC3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A6 (HGNC:10914)
Function [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:11551954, PubMed:10600773, PubMed:19665974, PubMed:18566107, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015).
Cellular Location Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q924N4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q924N4}
Tissue Location Expressed in brain (at protein level) (PubMed:21628467). Highly expressed in heart, brain and kidney Detected at lower levels in skeletal muscle, placenta, lung and pancreas (PubMed:10600773). Detected in umbilical vein endothelial cells (PubMed:16048901). [Isoform 5]: Testis specific.
Research Areas
Citations (0)
citation

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Background

This gene is a member of the K-Cl cotransporter (KCC)family. K-Cl cotransporters are integral membrane proteins thatlower intracellular chloride concentrations below theelectrochemical equilibrium potential. The proteins encoded by thisgene are activated by cell swelling induced by hypotonicconditions. Alternate splicing results in multiple transcriptvariants encoding different isoforms. Mutations in this gene areassociated with agenesis of the corpus callosum with peripheralneuropathy.

References

Rinehart, J., et al. Cell 138(3):525-536(2009)Rudnik-Schoneborn, S., et al. Neuropediatrics 40(3):129-133(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Moser, D., et al. Neuropsychopharmacology 34(2):458-467(2009)Salin-Cantegrel, A., et al. Hum. Mol. Genet. 17(17):2703-2711(2008)

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$ 277.78
Cat# BP12382a
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