|Other Names||Inward rectifier potassium channel 13, Inward rectifier K(+) channel Kir71, Potassium channel, inwardly rectifying subfamily J member 13, KCNJ13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord|
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This gene encodes a member of the inwardly rectifyingpotassium channel family of proteins. Members of this family formion channel pores that allow potassium ions to pass into a cell.The encoded protein belongs to a subfamily of low signal channelconductance proteins that have a low dependence on potassiumconcentration. Mutations in this gene are associated with snowflakevitreoretinal degeneration. Alternate splicing results in multipletranscript variants.
Zhang, W., et al. Biochem. Biophys. Res. Commun. 377(3):981-986(2008)Ji, W., et al. Nat. Genet. 40(5):592-599(2008)Hughes, B.A., et al. Am. J. Physiol., Cell Physiol. 294 (2), C423-C431 (2008) :Hejtmancik, J.F., et al. Am. J. Hum. Genet. 82(1):174-180(2008)Yang, D., et al. Exp. Eye Res. 86(1):81-91(2008)
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