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SLC12A7 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y666
Clone Names 100324182
Peptide ID 100324182
Additional Information
Gene ID 10723
Other Names Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4, SLC12A7, KCC4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A7
Synonyms KCC4
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Detected in muscle, brain, lung, heart and kidney
Research Areas
Citations (0)

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Background

SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

References

Hartmann, A.M., et al. J. Biol. Chem. 285(31):23994-24002(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Chen, Y.F., et al. Cancer Res. 69(22):8585-8593(2009)Fujii, T., et al. J. Biol. Chem. 284(1):619-629(2009)Ji, W., et al. Nat. Genet. 40(5):592-599(2008)

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$ 80.00
Cat# BP12392a
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