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SLC16A3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15427 |
|---|---|
| Clone Names | 100405016 |
| Gene ID | 9123 |
|---|---|
| Other Names | Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3, SLC16A3, MCT4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A3 |
|---|---|
| Synonyms | MCT3 {ECO:0000303|PubMed:9425115}, MCT4 |
| Function | Proton-dependent transporter of monocarboxylates such as L- lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction (PubMed:10921872). Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells (PubMed:21199217) |
| Tissue Location | Highly expressed in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Lactic acid and pyruvate transport across plasma membranesis catalyzed by members of the proton-linked monocarboxylatetransporter (MCT) family, which has been designated solute carrierfamily-16. Each MCT appears to have slightly different substrateand inhibitor specificities and transport kinetics, which arerelated to the metabolic requirements of the tissues in which it isfound. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2(SLC16A7; MIM 603654), are characterized by 12 predictedtransmembrane domains (Price et al., 1998 [PubMed9425115]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Vellonen, K.S., et al. Eur J Pharm Sci 39(4):241-247(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Wang, Q., et al. Drug Metab. Dispos. 35(8):1393-1399(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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