|Other Names||Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3, SLC16A3, MCT4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Lactic acid and pyruvate transport across plasma membranesis catalyzed by members of the proton-linked monocarboxylatetransporter (MCT) family, which has been designated solute carrierfamily-16. Each MCT appears to have slightly different substrateand inhibitor specificities and transport kinetics, which arerelated to the metabolic requirements of the tissues in which it isfound. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2(SLC16A7; MIM 603654), are characterized by 12 predictedtransmembrane domains (Price et al., 1998 [PubMed9425115]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Vellonen, K.S., et al. Eur J Pharm Sci 39(4):241-247(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Wang, Q., et al. Drug Metab. Dispos. 35(8):1393-1399(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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