|Other Names||Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 1, GalNAc alpha-2, 6-sialyltransferase I, ST6GalNAc I, ST6GalNAcI, Sialyltransferase 7A, SIAT7-A, ST6GALNAC1, SIAT7A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Glycosylation of proteins affects cell-cell interaction,interactions with the matrix, and the functions of intracellularmolecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminicacid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues.The cancer-associated sialyl-Tn (sTn) antigen is formed byST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins(Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006[PubMed 16319059]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Hassinen, A., et al. J. Biol. Chem. 285(23):17771-17777(2010)Patani, N., et al. Cancer Genomics Proteomics 5(6):333-340(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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