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NKAP Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N5F7 |
|---|---|
| Clone Names | 90713146 |
| Gene ID | 79576 |
|---|---|
| Other Names | NF-kappa-B-activating protein, NKAP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NKAP |
|---|---|
| Function | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch- regulated SKP2 promoter. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is involved in theactivation of the ubiquitous transcription factor NF-kappaB. Thisprotein is associated with the the histone deacetylase HDAC3 andwith the Notch corepressor complex, and it thereby acts as atranscriptional repressor of Notch target genes. It is alsorequired for alphabeta T cell development. A related pseudogene hasbeen identified on chromosome X, while a related and intronlessretrocopy, which has an intact CDS and may be functional, islocated on chromosome 6.
References
D'Addabbo, A., et al. Artif Intell Med 46(2):131-138(2009)Pajerowski, A.G., et al. Immunity 30(5):696-707(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003)
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