|Other Names||NF-kappa-B-activating protein, NKAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.|
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This gene encodes a protein that is involved in theactivation of the ubiquitous transcription factor NF-kappaB. Thisprotein is associated with the the histone deacetylase HDAC3 andwith the Notch corepressor complex, and it thereby acts as atranscriptional repressor of Notch target genes. It is alsorequired for alphabeta T cell development. A related pseudogene hasbeen identified on chromosome X, while a related and intronlessretrocopy, which has an intact CDS and may be functional, islocated on chromosome 6.
D'Addabbo, A., et al. Artif Intell Med 46(2):131-138(2009)Pajerowski, A.G., et al. Immunity 30(5):696-707(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003)
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