|Other Names||Transmembrane protein 181, TMEM181, GPR178, KIAA1423|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The TMEM181 gene encodes a putative G protein-coupledreceptor expressed on the cell surface (Carette et al., 2009[PubMed 19965467]; Wollscheid et al., 2009 [PubMed19349973]).
Carette, J.E., et al. Science 326(5957):1231-1235(2009)Wollscheid, B., et al. Nat. Biotechnol. 27(4):378-386(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Wistrand, M., et al. Protein Sci. 15(3):509-521(2006)Cheng, J., et al. Science 308(5725):1149-1154(2005)
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