|Other Names||Histone-lysine N-methyltransferase SETD1B, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1076, KMT2G, SET1B|
|Function||Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.|
|Cellular Location||Nucleus speckle. Chromosome. Note=Localizes to a largely non- overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes|
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Provided below are standard protocols that you may find useful for product applications.
SET1B is a component of a histone methyltransferasecomplex that produces trimethylated histone H3 at Lys4 (Lee et al.,2007 [PubMed 17355966]).
Wu, M., et al. Mol. Cell. Biol. 28(24):7337-7344(2008)Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)Lee, J.H., et al. J. Biol. Chem. 282(18):13419-13428(2007)
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