SET1B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UPS6 |
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Clone Names | 71130140 |
Other Names | Histone-lysine N-methyltransferase SETD1B, Lysine N-methyltransferase 2G, SET domain-containing protein 1B, hSET1B, SETD1B, KIAA1076, KMT2G, SET1B |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SETD1B |
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Synonyms | KIAA1076, KMT2G, SET1B |
Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:25561738, PubMed:17355966). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17355966). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). |
Cellular Location | Nucleus. Nucleus speckle. Chromosome. Cytoplasm Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes (PubMed:17355966) (Probable). Predominantly nuclear (PubMed:38003223). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SET1B is a component of a histone methyltransferasecomplex that produces trimethylated histone H3 at Lys4 (Lee et al.,2007 [PubMed 17355966]).
References
Wu, M., et al. Mol. Cell. Biol. 28(24):7337-7344(2008)Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)Lee, J.H., et al. J. Biol. Chem. 282(18):13419-13428(2007)
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