|Other Names||Translation initiation factor eIF-2B subunit alpha, eIF-2B GDP-GTP exchange factor subunit alpha, EIF2B1, EIF2BA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|
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This gene encodes one of five subunits of eukaryotictranslation initiation factor 2B (EIF2B), a GTP exchange factor foreukaryotic initiation factor 2 and an essential regulator forprotein synthesis. Mutations in this gene and the genes encodingother EIF2B subunits have been associated with leukoencephalopathywith vanishing white matter.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hiyama, T.B., et al. J. Mol. Biol. 392(4):937-951(2009)Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)van der Knaap, M.S., et al. Neuropediatrics 38 (5), 264 (2007) :
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