|Other Names||Sentrin-specific protease 7, SUMO-1-specific protease 2, Sentrin/SUMO-specific protease SENP7, SENP7, KIAA1707, SSP2, SUSP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1241a was selected from the C-term region of human SENP7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1707, SSP2, SUSP2|
|Function||Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full- length SUMO proteins to their mature forms.|
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Provided below are standard protocols that you may find useful for product applications.
SENP7 is a protease that may be involved in two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature conjugatable forms and/or deconjugation of SUMO1, SUMO2 and SUMO3 from targeted substrate proteins.
Wiemann, S., et al., Genome Res. 11(3):422-435 (2001).Nagase, T., et al., DNA Res. 7(6):347-355 (2000).
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