|Other Names||Rho-related GTP-binding protein RhoN, Rho family GTPase 2, Rho-related GTP-binding protein Rho7, Rnd2, RND2, ARHN, RHO7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome|
|Tissue Location||Highly expressed in testis.|
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This gene encodes a member of the Rho GTPase family, whosemembers play a key role in the regulation of actin cytoskeletonorganization in response to extracellular growth factors. Thisparticular family member has been implicated in the regulation ofneuronal morphology and endosomal trafficking. The gene localizesto chromosome 17 and is the centromeric neighbor of thebreast-ovarian cancer susceptibility gene BRCA1. [provided byRefSeq].
Tanaka, H., et al. J. Biol. Chem. 281(15):10355-10364(2006)Kim, Y.S., et al. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 142(4):410-415(2005)Kakimoto, T., et al. J. Biol. Chem. 279(14):14104-14110(2004)Naud, N., et al. Biochem. J. 372 (PT 1), 105-112 (2003) :Fujita, H., et al. J. Biol. Chem. 277(47):45428-45434(2002)
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