|Other Names||Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.|
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Provided below are standard protocols that you may find useful for product applications.
Placental ribonuclease inhibitor (PRI) is a member of afamily of proteinaceous cytoplasmic RNase inhibitors that occur inmany tissues and bind to both intracellular and extracellularRNases (summarized by Lee et al., 1988 [PubMed 3219362]). Inaddition to control of intracellular RNases, the inhibitor may havea role in the regulation of angiogenin (MIM 105850). Ribonucleaseinhibitor, of 50,000 Da, binds to ribonucleases and holds them in alatent form. Since neutral and alkaline ribonucleases probably playa critical role in the turnover of RNA in eukaryotic cells, RNH maybe essential for control of mRNA turnover; the interaction ofeukaryotic cells with ribonuclease may be reversible invivo.
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009)Turcotte, R.F., et al. Biochem. Biophys. Res. Commun. 377(2):512-514(2008)Johnson, R.J., et al. Biochemistry 46(45):13131-13140(2007)Johnson, R.J., et al. J. Mol. Biol. 368(2):434-449(2007)
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