|Other Names||Phosducin, PHD, 33 kDa phototransducing protein, Protein MEKA, PDC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.|
|Cellular Location||Cytoplasm, cytosol. Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment. Nucleus. Note=Outer and inner segments of the rod cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a phosphoprotein, which is located inthe outer and inner segments of the rod cells in the retina. Thisprotein may participate in the regulation of visualphototransduction or in the integration of photoreceptormetabolism. It modulates the phototransduction cascade byinteracting with the beta and gamma subunits of the retinalG-protein transducin. This gene is a potential candidate gene forretinitis pigmentosa and Usher syndrome type II. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.
Beetz, N., et al. J. Clin. Invest. 119(12):3597-3612(2009)Klenk, C., et al. J. Biol. Chem. 281(13):8357-8364(2006)Nishiguchi, K.M., et al. Mol. Vis. 10, 62-64 (2004) :Margulis, A., et al. Mol. Vis. 8, 477-482 (2002) :Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :
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