|Other Names||Transferrin receptor protein 2, TfR2, TFR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly|
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This gene is a member of the transferrin receptor-likefamily and encodes a single-pass type II membrane protein with aprotease associated (PA) domain, an M28 peptidase domain and atransferrin receptor-like dimerization domain. This proteinmediates cellular uptake of transferrin-bound iron and mutations inthis gene have been associated with hereditary hemochromatosis typeIII. Alternatively spliced variants which encode different proteinisoforms have been described; however, not all variants have beenfully characterized.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ikuta, K., et al. J. Mol. Biol. 397(2):375-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Volke, M., et al. PLoS ONE 4 (11), E7875 (2009) :
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