TFR2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UP52 |
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Clone Names | 100311174 |
Gene ID | 7036 |
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Other Names | Transferrin receptor protein 2, TfR2, TFR2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TFR2 |
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Function | Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. |
Cellular Location | Cell membrane; Single-pass type II membrane protein |
Tissue Location | Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the transferrin receptor-likefamily and encodes a single-pass type II membrane protein with aprotease associated (PA) domain, an M28 peptidase domain and atransferrin receptor-like dimerization domain. This proteinmediates cellular uptake of transferrin-bound iron and mutations inthis gene have been associated with hereditary hemochromatosis typeIII. Alternatively spliced variants which encode different proteinisoforms have been described; however, not all variants have beenfully characterized.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ikuta, K., et al. J. Mol. Biol. 397(2):375-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Volke, M., et al. PLoS ONE 4 (11), E7875 (2009) :
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