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TFR2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UP52
Clone Names 100311174
Additional Information
Gene ID 7036
Other Names Transferrin receptor protein 2, TfR2, TFR2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFR2
Function Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly
Research Areas
Citations (0)
citation

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Background

This gene is a member of the transferrin receptor-likefamily and encodes a single-pass type II membrane protein with aprotease associated (PA) domain, an M28 peptidase domain and atransferrin receptor-like dimerization domain. This proteinmediates cellular uptake of transferrin-bound iron and mutations inthis gene have been associated with hereditary hemochromatosis typeIII. Alternatively spliced variants which encode different proteinisoforms have been described; however, not all variants have beenfully characterized.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ikuta, K., et al. J. Mol. Biol. 397(2):375-384(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Volke, M., et al. PLoS ONE 4 (11), E7875 (2009) :

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$ 277.78
Cat# BP12449b
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