|Other Names||Selenoprotein N, SelN, SEPN1, SELN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Isoform 2: Endoplasmic reticulum membrane. Note=Probably membrane-associated|
|Tissue Location||Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a selenoprotein, which contains aselenocysteine (Sec) residue at its active site. The selenocysteineis encoded by the UGA codon that normally signals translationtermination. The 3' UTR of selenoprotein genes have a commonstem-loop structure, the sec insertion sequence (SECIS), that isnecessary for the recognition of UGA as a Sec codon rather than asa stop signal. Mutations in this gene cause the classical phenotypeof multiminicore disease and congenital muscular dystrophy withspinal rigidity and restrictive respiratory syndrome. Twoalternatively spliced transcript variants encoding distinctisoforms have been found for this gene.
Arbogast, S., et al. Ann. Neurol. 65(6):677-686(2009)Maiti, B., et al. Hum. Mutat. 30(3):411-416(2009)Jurynec, M.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(34):12485-12490(2008)Lin, L., et al. PLoS Genet. 4 (10), E1000225 (2008) :Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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