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ATP5J Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P18859
Clone Names 101008089
Additional Information
Gene ID 522
Other Names ATP synthase-coupling factor 6, mitochondrial, ATPase subunit F6, ATP5J, ATP5A, ATPM
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP5PF (HGNC:847)
Synonyms ATP5A, ATP5J, ATPM
Function Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
Cellular Location Mitochondrion. Mitochondrion inner membrane.
Research Areas
Citations (0)
citation

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Background

Mitochondrial ATP synthase catalyzes ATP synthesis,utilizing an electrochemical gradient of protons across the innermembrane during oxidative phosphorylation. It is composed of twolinked multi-subunit complexes: the soluble catalytic core, F1, andthe membrane-spanning component, Fo, which comprises the protonchannel. The F1 complex consists of 5 different subunits (alpha,beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3beta, and a single representative of the other 3. The Fo seems tohave nine subunits (a, b, c, d, e, f, g, F6 and 8). This geneencodes the F6 subunit of the Fo complex, required for F1 and Fointeractions. Alternatively spliced transcript variants encodingdifferent isoforms have been identified for this gene. A pseudogeneexists on chromosome Yp11.

References

Osanai, T., et al. Cardiovasc. Res. 81(4):780-787(2009)Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Kumagai, A., et al. Atherosclerosis 200(1):45-50(2008)Chai, S.B., et al. Circ. J. 71(5):693-697(2007)Morava, E., et al. Am. J. Med. Genet. A 140(8):863-868(2006)

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$ 277.78
Cat# BP12457c
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