|Other Names||DNA-directed RNA polymerase II subunit RPB7, RNA polymerase II subunit B7, DNA-directed RNA polymerase II subunit G, RNA polymerase II 19 kDa subunit, RPB19, POLR2G, RPB7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the seventh largest subunit of RNApolymerase II, the polymerase responsible for synthesizingmessenger RNA in eukaryotes. The protein functions in transcriptioninitiation, and is also thought to help stabilize transcribingpolyermase molecules during elongation.
Cojocaru, M., et al. Biochem. J. 409(1):139-147(2008)Ujvari, A., et al. Nat. Struct. Mol. Biol. 13(1):49-54(2006)Meka, H., et al. Nucleic Acids Res. 33(19):6435-6444(2005)Lehner, B., et al. Genomics 83(1):153-167(2004)Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671(2003)
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