|Other Names||Zinc finger FYVE domain-containing protein 1, Double FYVE-containing protein 1, SR3, Tandem FYVE fingers-1, ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DFCP1, KIAA1589, TAFF1, ZNFN2A1|
|Cellular Location||Golgi apparatus, Golgi stack. Endoplasmic reticulum. Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum|
|Tissue Location||Isoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also detected in the testis|
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The FYVE domain mediates the recruitment of proteinsinvolved in membrane trafficking and cell signaling tophosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes.This gene encodes a protein which contains two zinc-binding FYVEdomains in tandem. This protein displays a predominantly Golgi,endoplasmic reticulum and vesicular distribution. Alternativelyspliced transcript variants have been found for this gene, and theyencode two isoforms with different sizes.
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Heilig, R., et al. Nature 421(6923):601-607(2003)Krugmann, S., et al. Mol. Cell 9(1):95-108(2002)Ridley, S.H., et al. J. Cell. Sci. 114 (PT 22), 3991-4000 (2001) :Cheung, P.C., et al. Biochem. J. 355 (PT 1), 113-121 (2001) :
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