|Other Names||RasGAP-activating-like protein 1, RASAL1, RASAL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Tissue Location||Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798). Expressed in melanocytes (PubMed:23999003)|
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The protein encoded by this gene is member of the GAP1family of GTPase-activating proteins. These proteins stimulate theGTPase activity of normal RAS p21 but not its oncogeniccounterpart. Acting as a suppressor of RAS function, the proteinenhances the weak intrinsic GTPase activity of RAS proteinsresulting in the inactive GDP-bound form of RAS, thereby allowingcontrol of cellular proliferation and differentiation. Thisparticular family member contains domains which are characteristicof the GAP1 subfamily of RasGAP proteins but, in contrast to theother GAP1 family members, this protein is strongly and selectivelyexpressed in endocrine tissues. Alternatively spliced transcriptvariants that encode different isoforms have been described
Ohta, M., et al. Gastroenterology 136(1):206-216(2009)Jin, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(30):12353-12358(2007)Liu, Q., et al. J. Cell Biol. 170(2):183-190(2005)Schmitt, J.M., et al. J. Biol. Chem. 277(45):43024-43032(2002)Allen, M., et al. Gene 218 (1-2), 17-25 (1998) :
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