|Other Names||Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA, 11411-, 60S ribosomal protein L27a histidine hydroxylase, Histone lysine demethylase MINA, MYC-induced nuclear antigen, Mineral dust-induced gene protein, Nucleolar protein 52, Ribosomal oxygenase MINA, ROX, MINA (HGNC:19441)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.|
|Cellular Location||Nucleus. Nucleus, nucleolus|
|Tissue Location||Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines|
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Provided below are standard protocols that you may find useful for product applications.
MINA is a c-Myc (MYC; MIM 190080) target gene that mayplay a role in cell proliferation or regulation of cell growth.(Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005[PubMed 15897898]).
Komiya, K., et al. J. Cancer Res. Clin. Oncol. 136(3):465-473(2010)Lu, Y., et al. Cell Cycle 8(13):2101-2109(2009)Zhang, Q., et al. Int. J. Biol. Markers 23(2):83-88(2008)Ishizaki, H., et al. Pathol. Int. 57(10):672-680(2007)Teye, K., et al. Oncol. Rep. 18(4):841-848(2007)
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