|Other Names||WAP four-disulfide core domain protein 1, Prostate stromal protein ps20, ps20 growth inhibitor, WFDC1, PS20|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has growth inhibitory activity.|
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This gene encodes a member of the WAP-type four disulfidecore domain family. The WAP-type four-disulfide core domain, or WAPsignature motif, contains eight cysteines forming four disulfidebonds at the core of the protein, and functions as a proteaseinhibitor in many family members. The encoded protein shares 81%amino acid identity with the rat ps20 protein, which was originallyidentified as a secreted growth inhibitor. This gene is mapped tochromosome 16q24, an area of frequent loss of heterozygosity incancers, including prostate, breast and hepatocellular cancers andWilms' tumor. Owing to its location and a possible growthinhibitory property of its gene product, this gene is suggested tobe a tumor suppressor gene.
Briggs, F.B., et al. Genes Immun. 11(3):199-208(2010)Madar, S., et al. Carcinogenesis 30(1):20-27(2009)Liu, S., et al. Clin. Exp. Metastasis 26(7):739-749(2009)Alvarez, R., et al. J. Virol. 82(1):471-486(2008)Watson, J.E., et al. Prostate 61(2):192-199(2004)
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