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DNAJB6 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O75190
Clone Names 100318099
Peptide ID 100318099
Additional Information
Gene ID 10049
Other Names DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSJ2, MRJ, MSJ1
Function Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Cellular Location Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line
Tissue Location Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
Research Areas
Citations (0)

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This gene encodes a member of the DNAJ protein family.DNAJ family members are characterized by a highly conserved aminoacid stretch called the 'J-domain' and function as one of the twomajor classes of molecular chaperones involved in a wide range ofcellular events, such as protein folding and oligomeric proteincomplex assembly. This family member may also play a role inpolyglutamine aggregation in specific neurons. Alternative splicingof this gene results in multiple transcript variants; however, notall variants have been fully described.


Mitra, A., et al. J. Biol. Chem. 285(32):24686-24694(2010)Edo De Bock, C., et al. Int. J. Oncol. 36(5):1155-1163(2010)Hageman, J., et al. Mol. Cell 37(3):355-369(2010)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Dey, S., et al. Mol. Cell. Biochem. 322 (1-2), 137-142 (2009) :

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$ 80.00
Cat# BP12493c
(40 western blots)
Availability: In Stock
Bulk Size
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