|Other Names||DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HSJ2, MRJ, MSJ1|
|Function||Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line|
|Tissue Location||Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.|
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This gene encodes a member of the DNAJ protein family.DNAJ family members are characterized by a highly conserved aminoacid stretch called the 'J-domain' and function as one of the twomajor classes of molecular chaperones involved in a wide range ofcellular events, such as protein folding and oligomeric proteincomplex assembly. This family member may also play a role inpolyglutamine aggregation in specific neurons. Alternative splicingof this gene results in multiple transcript variants; however, notall variants have been fully described.
Mitra, A., et al. J. Biol. Chem. 285(32):24686-24694(2010)Edo De Bock, C., et al. Int. J. Oncol. 36(5):1155-1163(2010)Hageman, J., et al. Mol. Cell 37(3):355-369(2010)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Dey, S., et al. Mol. Cell. Biochem. 322 (1-2), 137-142 (2009) :
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