|Other Names||Non-specific lipid-transfer protein, NSL-TP, Propanoyl-CoA C-acyltransferase, SCP-chi, SCPX, Sterol carrier protein 2, SCP-2, Sterol carrier protein X, SCP-X, SCP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues Isoform SCP2: Mitochondrion.|
|Tissue Location||Liver, fibroblasts, and placenta.|
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This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result oftranscription initiation from 2 independently regulated promoters.The transcript initiated from the proximal promoter encodes thelonger SCPx protein, and the transcript initiated from the distalpromoter encodes the shorter SCP2 protein, with the 2 proteinssharing a common C-terminus. Evidence suggests that the SCPxprotein is a peroxisome-associated thiolase that is involved in theoxidation of branched chain fatty acids, while the SCP2 protein isthought to be an intracellular lipid transfer protein. This gene ishighly expressed in organs involved in lipid metabolism, and mayplay a role in Zellweger syndrome, in which cells are deficient inperoxisomes and have impaired bile acid synthesis. Alternativesplicing of this gene produces multiple transcript variants, someencoding different isoforms.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)Dansen, T.B., et al. J. Lipid Res. 45(1):81-88(2004)
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