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FA83D Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H4H8 |
|---|---|
| Clone Names | 91201197 |
| Gene ID | 81610 |
|---|---|
| Other Names | Protein FAM83D, Spindle protein CHICA, FAM83D, C20orf129 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FAM83D (HGNC:16122) |
|---|---|
| Function | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase |
| Tissue Location | Expressed in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FA83D is required for proper chromosome congression and alignment during mitosis. Required for targeting KIF22/KID to the spindle microtubules.
References
Santamaria, A., et al. Curr. Biol. 18(10):723-729(2008)Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)Deloukas, P., et al. Nature 414(6866):865-871(2001)
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