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CD271 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P08138
Clone Names 81020018
Additional Information
Gene ID 4804
Other Names Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NGFR
Synonyms TNFRSF16
Function Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin- dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
Cellular Location Cell membrane; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}
Research Areas
Citations (0)
citation

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Background

Nerve growth factor receptor contains an extracellulardomain containing four 40-amino acid repeats with 6 cysteineresidues at conserved positions followed by a serine/threonine-richregion, a single transmembrane domain, and a 155-amino acidcytoplasmic domain. The cysteine-rich region contains the nervegrowth factor binding domain.

References

Boiko, A.D., et al. Nature 466(7302):133-137(2010)Ceni, C., et al. J. Cell. Sci. 123 (PT 13), 2299-2307 (2010) :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Sornelli, F., et al. Mol. Vis. 16, 1439-1447 (2010) :

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$ 277.78
Cat# BP12542b
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