|Other Names||Stromal interaction molecule 2, STIM2, KIAA1482|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration|
|Tissue Location||Expressed in all tissues and tumor cell lines examined.|
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This gene is a member of the stromal interaction molecule(STIM) family and likely arose, along with related family memberSTIM1, from a common ancestral gene. The encoded protein functionsto regulate calcium concentrations in the cytosol and endoplasmicreticulum, and is involved in the activation of plasma membraneOrai Ca(2+) entry channels. This gene initiates translation from anon-AUG (UUG) start site. A signal peptide is cleaved from theresulting protein. Multiple transcript variants result fromalternative splicing.
Darbellay, B., et al. J. Biol. Chem. 285(29):22437-22447(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :El Boustany, C., et al. Cell Calcium 47(4):350-359(2010)Zhou, Y., et al. J. Biol. Chem. 284(29):19164-19168(2009)Parvez, S., et al. FASEB J. 22(3):752-761(2008)
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