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STIM2 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P246
Clone Names 80513047
Additional Information
Gene ID 57620
Other Names Stromal interaction molecule 2, STIM2, KIAA1482
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STIM2
Synonyms KIAA1482
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration
Tissue Location Expressed in all tissues and tumor cell lines examined.
Research Areas
Citations (0)
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Background

This gene is a member of the stromal interaction molecule(STIM) family and likely arose, along with related family memberSTIM1, from a common ancestral gene. The encoded protein functionsto regulate calcium concentrations in the cytosol and endoplasmicreticulum, and is involved in the activation of plasma membraneOrai Ca(2+) entry channels. This gene initiates translation from anon-AUG (UUG) start site. A signal peptide is cleaved from theresulting protein. Multiple transcript variants result fromalternative splicing.

References

Darbellay, B., et al. J. Biol. Chem. 285(29):22437-22447(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :El Boustany, C., et al. Cell Calcium 47(4):350-359(2010)Zhou, Y., et al. J. Biol. Chem. 284(29):19164-19168(2009)Parvez, S., et al. FASEB J. 22(3):752-761(2008)

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$ 277.78
Cat# BP12545a
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