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STIM2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9P246
Clone Names 80513047
Peptide ID 80513047
Additional Information
Gene ID 57620
Other Names Stromal interaction molecule 2, STIM2, KIAA1482
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STIM2
Synonyms KIAA1482
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration
Tissue Location Expressed in all tissues and tumor cell lines examined.
Research Areas
Citations (0)

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This gene is a member of the stromal interaction molecule(STIM) family and likely arose, along with related family memberSTIM1, from a common ancestral gene. The encoded protein functionsto regulate calcium concentrations in the cytosol and endoplasmicreticulum, and is involved in the activation of plasma membraneOrai Ca(2+) entry channels. This gene initiates translation from anon-AUG (UUG) start site. A signal peptide is cleaved from theresulting protein. Multiple transcript variants result fromalternative splicing.


Darbellay, B., et al. J. Biol. Chem. 285(29):22437-22447(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :El Boustany, C., et al. Cell Calcium 47(4):350-359(2010)Zhou, Y., et al. J. Biol. Chem. 284(29):19164-19168(2009)Parvez, S., et al. FASEB J. 22(3):752-761(2008)

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$ 80.00
Cat# BP12545a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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