|Other Names||Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM, CAPN6, CALPM, CANPX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle|
|Tissue Location||Expressed only in placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Calpains are ubiquitous, well-conserved family ofcalcium-dependent, cysteine proteases. The calpain proteins areheterodimers consisting of an invariant small subunit and variablelarge subunits. The large subunit possesses a cysteine proteasedomain, and both subunits possess calcium-binding domains. Calpainshave been implicated in neurodegenerative processes, as theiractivation can be triggered by calcium influx and oxidative stress.The protein encoded by this gene is highly expressed in theplacenta. Its C-terminal region lacks any homology to thecalmodulin-like domain of other calpains. The protein lackscritical active site residues and thus is suggested to beproteolytically inactive. The protein may play a role in tumorformation by inhibiting apoptosis and promoting angiogenesis.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Secolin, R., et al. Psychiatr. Genet. 20(3):126-129(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Rho, S.B., et al. Cancer Lett. 271(2):306-313(2008)Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)
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