|Other Names||Nucleolar transcription factor 1, Autoantigen NOR-90, Upstream-binding factor 1, UBF-1, UBTF, UBF, UBF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.|
|Cellular Location||Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
Upstream binding factor (UBF) is a transcription factorrequired for expression of the 18S, 5.8S, and 28S ribosomal RNAs,along with SL1 (a complex of TBP (MIM 600075) and multipleTBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBFis a nucleolar phosphoprotein with both DNA binding andtransactivation domains. Sequence-specific DNA binding to the coreand upstream control elements of the human rRNA promoter ismediated through several HMG boxes (Jantzen et al., 1990 [PubMed2330041]).
Hisaoka, M., et al. Mol. Cell. Biol. 30(20):4952-4964(2010)Liu, Z., et al. Proteins 77(2):432-447(2009)Lin, C.I., et al. Biochem. Biophys. Res. Commun. 386(2):396-401(2009)Grob, A., et al. J. Cell. Sci. 122 (PT 4), 489-498 (2009) :He, J., et al. Folia Biol. (Praha) 54(6):202-206(2008)
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