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CTNND2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UQB3 |
|---|---|
| Clone Names | 90121088 |
| Gene ID | 1501 |
|---|---|
| Other Names | Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CTNND2 |
|---|---|
| Synonyms | NPRAP |
| Function | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35116}. Perikaryon |
| Tissue Location | Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an adhesive junction associated proteinof the armadillo/beta-catenin superfamily and is implicated inbrain and eye development and cancer formation. The protein encodedby this gene promotes the disruption of E-cadherin based adherensjunction to favor cell spreading upon stimulation by hepatocytegrowth factor. This gene is overexpressed in prostateadenocarcinomas and is associated with decreased expression oftumor suppressor E-cadherin in this tissue. This gene resides in aregion of the short arm of chromosome 5 that is deleted in Cri duChat syndrome.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhang, J., et al. Exp. Cell Res. 316(6):1070-1081(2010)Yang, I., et al. Mol. Cells 29(3):233-237(2010)Stenzel, N., et al. J. Cell. Sci. 122 (PT 18), 3374-3384 (2009) :Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
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