|Other Names||Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.|
|Cellular Location||Nucleus. Cell junction, adherens junction. Perikaryon. Note=Colocalizes with CDK5 in the cell body of neuronal cells|
|Tissue Location||Predominantly expressed in brain; accumulates in cortical neurons (at protein level)|
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This gene encodes an adhesive junction associated proteinof the armadillo/beta-catenin superfamily and is implicated inbrain and eye development and cancer formation. The protein encodedby this gene promotes the disruption of E-cadherin based adherensjunction to favor cell spreading upon stimulation by hepatocytegrowth factor. This gene is overexpressed in prostateadenocarcinomas and is associated with decreased expression oftumor suppressor E-cadherin in this tissue. This gene resides in aregion of the short arm of chromosome 5 that is deleted in Cri duChat syndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhang, J., et al. Exp. Cell Res. 316(6):1070-1081(2010)Yang, I., et al. Mol. Cells 29(3):233-237(2010)Stenzel, N., et al. J. Cell. Sci. 122 (PT 18), 3374-3384 (2009) :Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
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