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ERRFI1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UJM3 |
|---|---|
| Clone Names | 100318067 |
| Gene ID | 54206 |
|---|---|
| Other Names | ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein, MIG-6, ERRFI1, MIG6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ERRFI1 |
|---|---|
| Synonyms | MIG6 |
| Function | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ERRFI1 is a cytoplasmic protein whose expression isupregulated with cell growth (Wick et al., 1995 [PubMed 7641805]).It shares significant homology with the protein product of ratgene-33, which is induced during cell stress and mediates cellsignaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino etal., 2000 [PubMed 11003669]).
References
Frosi, Y., et al. J. Cell Biol. 189(3):557-571(2010)Ying, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6912-6917(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Reschke, M., et al. Hepatology 51(4):1383-1390(2010)Nagashima, T., et al. FEBS J. 276(18):5239-5251(2009)
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