|Other Names||NKG2-F type II integral membrane protein, NK cell receptor F, NKG2-F-activating NK receptor, KLRC4, NKG2F|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Natural killer cells. EMBL; U96846; AAC51910.1; -; Genomic_DNA EMBL; U96845; AAC51909.1; -; mRNA EMBL; AF027164; AAC17491.1; -; Genomic_DNA EMBL; AJ001683; CAA04921.1; -; mRNA EMBL; AJ001686; CAA04924.1; -; Genomic_DNA EMBL; AF350018; AAK83805.1; -; mRNA EMBL; AF350019; AAK83806.1; -; mRNA EMBL; AC022075; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC017784; AAH17784.1; -; mRNA CCDS; CCDS8624.1; - RefSeq; NP_038459.1; NM_013431.2 UniGene; Hs.721094; - ProteinModelPortal; O43908; - SMR; O43908; - STRING; 9606.ENSP00000310216; - iPTMnet; O43908; - PhosphoSitePlus; O43908; - BioMuta; KLRC4; - PaxDb; O43908; - PRIDE; O43908; - DNASU; 8302; - Ensembl; ENST00000309384; ENSP00000310216; ENSG00000183542 GeneID; 8302; - KEGG; hsa:8302; - UCSC; uc001qye.4; human CTD; 8302; - DisGeNET; 8302; - GeneCards; KLRC4; - HGNC; HGNC:6377; KLRC4 MIM; 602893; gene neXtProt; NX_O43908; - OpenTargets; ENSG00000183542; - PharmGKB; PA30166; - eggNOG; ENOG410KGBU; Eukaryota eggNOG; ENOG4110SFD; LUCA GeneTree; ENSGT00730000110282; - HOGENOM; HOG000220925; - HOVERGEN; HBG077044; - InParanoid; O43908; - KO; K06541; - OMA; KACDCGH; - OrthoDB; EOG091G0I60; - PhylomeDB; O43908; - BioCyc; ZFISH:ENSG00000121373-MONOMER; - GeneWiki; KLRC4; - GenomeRNAi; 8302; - PRO; PR:O43908; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000183542; - Genevisible; O43908; HS GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0006968; P:cellular defense response; TAS:ProtInc Gene3D; 126.96.36.199; -; 1 InterPro; IPR016186; C-type_lectin-like/link InterPro; IPR016187; CTDL_fold SUPFAM; SSF56436; SSF56436; 1 2: Evidence at transcript level; Complete proteome; Disulfide bond; Membrane; Polymorphism; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix CHAIN 1 158 NKG2-F type II integral membrane protein /FTId=PRO_0000046673 TOPO_DOM 1 74 Cytoplasmic. TRANSMEM 75 95 Helical; Signal-anchor for type II membrane protein. TOPO_DOM 96 158 Extracellular. VARIANT 29 29 I -> S (in allele NKG2-F*02; dbSNP:rs1841958) /FTId=VAR_013406 VARIANT 104 104 N -> S (in allele NKG2-F*02; dbSNP:rs2617170) /FTId=VAR_013407 SEQUENCE 158 AA; 18234 MW; 1AABC0E5ED26ACCC CRC64; MNKQRGTYSE VSLAQDPKRQ QRKLKGNKIS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH CKGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNNFSLNRR MQKARHCGHC PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL|
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Natural killer (NK) cells are lymphocytes that can mediatelysis of certain tumor cells and virus-infected cells withoutprevious activation. They can also regulate specific humoral andcell-mediated immunity. NK cells preferentially express severalcalcium-dependent (C-type) lectins, which have been implicated inthe regulation of NK cell function. KLRC4 is a member of the NKG2group which are expressed primarily in natural killer (NK) cellsand encodes a family of transmembrane proteins characterized by atype II membrane orientation (extracellular C terminus) and thepresence of a C-type lectin domain. The NKG2 gene family is locatedwithin the NK complex, a region that contains several C-type lectingenes preferentially expressed on NK cells. The 3' end of the KLRC4transcript includes the first non-coding exon found at the 5' endof the adjacent D12S2489E gene transcript.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ma, J., et al. J. Med. Virol. 82(9):1501-1507(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Sellick, G.S., et al. Blood 111(3):1625-1633(2008)Cao, Q., et al. Zhonghua Nei Ke Za Zhi 45(10):824-826(2006)
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