|Other Names||Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, Peroxisomal membrane anchor protein PEX14, PEX14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.|
|Cellular Location||Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side|
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This gene encodes an essential component of theperoxisomal import machinery. The protein is integrated intoperoxisome membranes with its C-terminus exposed to the cytosol,and interacts with the cytosolic receptor for proteins containing aPTS1 peroxisomal targeting signal. The protein also functions as atranscriptional corepressor and interacts with a histonedeacetylase. A mutation in this gene results in one form ofZellweger syndrome.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Macgregor, S., et al. Hum. Mol. Genet. 19(13):2716-2724(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Shiozawa, K., et al. J. Biol. Chem. 284(37):25334-25342(2009)
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