CYFIP2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96F07 |
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Clone Names | 100318122 |
Gene ID | 26999 |
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Other Names | Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121, CYFIP2 {ECO:0000312|EMBL:AAH117621} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CYFIP2 {ECO:0000312|EMBL:AAH11762.1} |
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Function | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). |
Cellular Location | Cytoplasm. Nucleus Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q5SQX6}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q5SQX6}. Note=Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity) Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:17245118} |
Tissue Location | Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
CYFIP2 is involved in T-cell adhesion and TP53/p53-dependent induction of apoptosis. Does not bind RNA.
References
Anitei, M., et al. Nat. Cell Biol. 12(4):330-340(2010)Wu, H., et al. J. Allergy Clin. Immunol. 125(2):321-327(2010)Daley, D., et al. Hum. Genet. 125(4):445-459(2009)Zhou, H., et al. BMC Med. Genet. 10, 123 (2009) :Jackson, R.S. II, et al. Cell Cycle 6(1):95-103(2007)
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