|Other Names||Abl interactor 2, Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ABI2, ARGBPIA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May be involved in cytoskeletal reorganization. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Ryu, J.R., et al. Mol. Cell. Biol. 29(7):1735-1748(2009)Kano, S., et al. Cancer Res. 68(14):5572-5580(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Li, Y., et al. J. Cell. Sci. 120 (PT 8), 1436-1446 (2007) :O'Donnell, C.J., et al. BMC Med. Genet. 8 SUPPL 1, S4 (2007) :
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