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LOC646627 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6UX82 |
|---|---|
| Clone Names | 100203159 |
| Gene ID | 646627 |
|---|---|
| Other Names | Ly6/PLAUR domain-containing protein 8, LYPD8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LYPD8 (HGNC:44208) |
|---|---|
| Function | Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9D7S0}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D7S0}. Secreted {ECO:0000250|UniProtKB:Q9D7S0}. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor {ECO:0000250|UniProtKB:Q9D7S0} |
| Tissue Location | Expressed in the large intestine. Preferentially expressed on the epithelial layer exposed to the lumen (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The exact functions of this protein remain unknown.
References
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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