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LOC646627 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UX82
Clone Names 100203159
Peptide ID 100203159
Additional Information
Gene ID 646627
Other Names Ly6/PLAUR domain-containing protein 8, LYPD8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LYPD8 (HGNC:44208)
Function Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9D7S0}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D7S0}. Secreted {ECO:0000250|UniProtKB:Q9D7S0}. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor {ECO:0000250|UniProtKB:Q9D7S0}
Tissue Location Expressed in the large intestine. Preferentially expressed on the epithelial layer exposed to the lumen (at protein level).
Research Areas
Citations (0)

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Background

The exact functions of this protein remain unknown.

References

Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 80.00
Cat# BP12589c
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