|Other Names||Sentrin-specific protease 8, Deneddylase-1, NEDD8-specific protease 1, Protease, cysteine 2, Sentrin/SUMO-specific protease SENP8, SENP8, DEN1, NEDP1, PRSC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1259a was selected from the N-term region of human SENP8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DEN1, NEDP1, PRSC2|
|Function||Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.|
|Tissue Location||Broadly expressed, with highest levels in kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
NEDD8 is a ubiquitin-like protein that becomes conjugated to the cullin subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. SENP8 is a protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Wu, K., et al., J. Biol. Chem. 278(31):28882-28891 (2003).Gan-Erdene, T., et al., J. Biol. Chem. 278(31):28892-28900 (2003).Mendoza, H.M., et al., J. Biol. Chem. 278(28):25637-25643 (2003).
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