|Other Names||5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.|
|Tissue Location||Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the family of serotoninreceptors, which are G protein coupled receptors that stimulatecAMP production in response to serotonin (5-hydroxytryptamine). Thegene product is a glycosylated transmembrane protein that functionsin both the peripheral and central nervous system to modulate therelease of various neurotransmitters. Multiple transcript variantsencoding proteins with distinct C-terminal sequences have beendescribed.
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)Maillet, M., et al. Biochem. J. 387 (PT 2), 463-471 (2005) :Brattelid, T., et al. Naunyn Schmiedebergs Arch. Pharmacol. 369(6):616-628(2004)Hiroi, T., et al. Biochem. Biophys. Res. Commun. 289(2):337-344(2001)Bender, E., et al. J. Neurochem. 74(2):478-489(2000)
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