|Other Names||Homeobox protein Hox-D10, Homeobox protein Hox-4D, Homeobox protein Hox-4E, HOXD10, HOX4D, HOX4E|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|
|Tissue Location||Strongly expressed in the adult male and female urogenital tracts|
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This gene is a member of the Abd-B homeobox family andencodes a protein with a homeobox DNA-binding domain. It isincluded in a cluster of homeobox D genes located on chromosome 2.The encoded nuclear protein functions as a sequence-specifictranscription factor that is expressed in the developing limb budsand is involved in differentiation and limb development. Mutationsin this gene have been associated with Wilm's tumor and congenitalvertical talus (also known as 'rocker-bottom foot' deformity orcongenital convex pes valgus) and/or a foot deformity resemblingthat seen in Charcot-Marie-Tooth disease.
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Reddy, S.D., et al. Cancer Res. 68(20):8195-8200(2008)Gurnett, C.A., et al. Clin. Orthop. Relat. Res. 462, 27-31 (2007) :Zhao, X., et al. Am. J. Hum. Genet. 80(2):361-371(2007)Wang, L.L., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22(6):653-656(2005)
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