UGDH Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O60701 |
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Clone Names | 100318160 |
Gene ID | 7358 |
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Other Names | UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UGDH |
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Function | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). |
Tissue Location | Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene converts UDP-glucose toUDP-glucuronate and thereby participates in the biosynthesis ofglycosaminoglycans such as hyaluronan, chondroitin sulfate, andheparan sulfate. These glycosylated compounds are common componentsof the extracellular matrix and likely play roles in signaltransduction, cell migration, and cancer growth and metastasis. Theexpression of this gene is up-regulated by transforming growthfactor beta and down-regulated by hypoxia. Alternative splicingresults in multiple transcript variants.
References
Wang, T.P., et al. Exp. Cell Res. 316(17):2893-2902(2010)Hodgkinson, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(19):8695-8700(2010)Huang, D., et al. Int. J. Cancer 126(2):315-327(2010)Lee, H.S., et al. Arch. Biochem. Biophys. 486(1):35-43(2009)Pan, Y.R., et al. Cell. Microbiol. 10(12):2447-2460(2008)
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