|Other Names||UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene converts UDP-glucose toUDP-glucuronate and thereby participates in the biosynthesis ofglycosaminoglycans such as hyaluronan, chondroitin sulfate, andheparan sulfate. These glycosylated compounds are common componentsof the extracellular matrix and likely play roles in signaltransduction, cell migration, and cancer growth and metastasis. Theexpression of this gene is up-regulated by transforming growthfactor beta and down-regulated by hypoxia. Alternative splicingresults in multiple transcript variants.
Wang, T.P., et al. Exp. Cell Res. 316(17):2893-2902(2010)Hodgkinson, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(19):8695-8700(2010)Huang, D., et al. Int. J. Cancer 126(2):315-327(2010)Lee, H.S., et al. Arch. Biochem. Biophys. 486(1):35-43(2009)Pan, Y.R., et al. Cell. Microbiol. 10(12):2447-2460(2008)
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