DRG1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y295 |
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Clone Names | 100324017 |
Gene ID | 4733 |
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Other Names | Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029} |
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Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). |
Cellular Location | Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes |
Tissue Location | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
DRG1 may play a role in cell proliferation, differentiation and death.
References
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Bandyopadhyay, S., et al. Cancer Res. 66(24):11983-11990(2006)Bandyopadhyay, S., et al. Oncogene 23(33):5675-5681(2004)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Bandyopadhyay, S., et al. Cancer Res. 63(8):1731-1736(2003)
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