|Other Names||Histone H4 transcription factor, Histone nuclear factor P, HiNF-P, MBD2-interacting zinc finger protein, Methyl-CpG-binding protein 2-interacting zinc finger protein, HINFP, MIZF, ZNF743|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.|
|Cellular Location||Nucleus. Note=Associated with discrete nuclear foci|
|Tissue Location||Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.|
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Provided below are standard protocols that you may find useful for product applications.
MIZF interacts with methyl-CpG-binding protein-2 (MBD2;MIM 603547), a component of the MeCP1 histone deacetylase (HDAC)complex, and plays a role in DNA methylation and transcriptionrepression.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Mitra, P., et al. J. Cell. Physiol. 219(2):438-448(2009)Medina, R., et al. Biochemistry 47(44):11415-11423(2008)Medina, R., et al. Cancer Res. 67(21):10334-10342(2007)
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