|Other Names||Transcription factor RFX3, Regulatory factor X 3, RFX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left- right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non- neuronal cells but not in neuronal cells (PubMed:12411430).|
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This gene is a member of the regulatory factor X genefamily, which encodes transcription factors that contain ahighly-conserved winged helix DNA binding domain. The proteinencoded by this gene is structurally related to regulatory factorsX1, X2, X4, and X5. It is a transcriptional activator that can bindDNA as a monomer or as a heterodimer with other RFX family members.Two transcript variants encoding different isoforms have beendescribed for this gene, and at least one of the variants utilizesalternative polyadenylation signals.
El Zein, L., et al. J. Cell. Sci. 122 (PT 17), 3180-3189 (2009) :Humphray, S.J., et al. Nature 429(6990):369-374(2004)Maijgren, S., et al. Arch. Dermatol. Res. 295(11):482-489(2004)Nakayama, A., et al. J. Biol. Chem. 278(1):233-240(2003)Morotomi-Yano, K., et al. J. Biol. Chem. 277(1):836-842(2002)
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