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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   EIF4EBP1 Antibody (Center) Blocking peptide   

EIF4EBP1 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13541
Clone Names 61228150
Peptide ID 61228150
Additional Information
Gene ID 1978
Other Names Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF4EBP1
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Research Areas
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Background

This gene encodes one member of a family of translationrepressor proteins. The protein directly interacts with eukaryotictranslation initiation factor 4E (eIF4E), which is a limitingcomponent of the multisubunit complex that recruits 40S ribosomalsubunits to the 5' end of mRNAs. Interaction of this protein witheIF4E inhibits complex assembly and represses translation. Thisprotein is phosphorylated in response to various signals includingUV irradiation and insulin signaling, resulting in its dissociationfrom eIF4E and activation of mRNA translation. [provided byRefSeq].

References

She, Q.B., et al. Cancer Cell 18(1):39-51(2010)Aoyagi, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2640-2645(2010)Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Kumar, A., et al. PLoS ONE 5 (1), E8730 (2010) :Villalonga, P., et al. J. Biol. Chem. 284(51):35287-35296(2009)

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$ 80.00
Cat# BP12627c
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