|Other Names||Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Proapolipoprotein A-I, ProapoA-I, Truncated apolipoprotein A-I, Apolipoprotein A-I(1-242), APOA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.|
|Tissue Location||Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.|
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This gene encodes apolipoprotein A-I, which is the majorprotein component of high density lipoprotein (HDL) in plasma. Theprotein promotes cholesterol efflux from tissues to the liver forexcretion, and it is a cofactor for lecithincholesterolacyltransferase (LCAT) which is responsible for theformation of most plasma cholesteryl esters. This gene is closelylinked with two other apolipoprotein genes on chromosome 11.Defects in this gene are associated with HDL deficiencies,including Tangier disease, and with systemic non-neuropathicamyloidosis.
Clemente-Postigo, M., et al. Clin. Biochem. 43 (16-17), 1300-1304 (2010) :Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Dawar, R., et al. Am. J. Clin. Pathol. 134(2):249-255(2010)Mattei, J., et al. Nutr Metab Cardiovasc Dis (2010) In press :Bencharif, K., et al. Lipids Health Dis 9, 75 (2010) :
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