|Other Names||Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).|
|Tissue Location||Lymphoid cells.|
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The protein encoded by this gene belongs to the IRF(interferon regulatory factor) family of transcription factors,characterized by an unique tryptophan pentad repeat DNA-bindingdomain. The IRFs are important in the regulation of interferons inresponse to infection by virus, and in the regulation ofinterferon-inducible genes. This family member is lymphocytespecific and negatively regulates Toll-like-receptor (TLR)signaling that is central to the activation of innate and adaptiveimmune systems. A chromosomal translocation involving this gene andthe IgH locus, t(6;14)(p25;q32), may be a cause of multiplemyeloma. Alternatively spliced transcript variants have been foundfor this gene.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Staudt, V., et al. Immunity 33(2):192-202(2010)Newton-Bishop, J.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2043-2054(2010)Duffy, D.L., et al. Am. J. Hum. Genet. 87(1):6-16(2010)Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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