|Other Names||Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).|
|Tissue Location||Lymphoid cells.|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the IRF(interferon regulatory factor) family of transcription factors,characterized by an unique tryptophan pentad repeat DNA-bindingdomain. The IRFs are important in the regulation of interferons inresponse to infection by virus, and in the regulation ofinterferon-inducible genes. This family member is lymphocytespecific and negatively regulates Toll-like-receptor (TLR)signaling that is central to the activation of innate and adaptiveimmune systems. A chromosomal translocation involving this gene andthe IgH locus, t(6;14)(p25;q32), may be a cause of multiplemyeloma. Alternatively spliced transcript variants have been foundfor this gene.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Staudt, V., et al. Immunity 33(2):192-202(2010)Newton-Bishop, J.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2043-2054(2010)Duffy, D.L., et al. Am. J. Hum. Genet. 87(1):6-16(2010)Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
If you have any additional inquiries please email technical services at email@example.com.