|Other Names||Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts|
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Dermatopontin is an extracellular matrix protein withpossible functions in cell-matrix interactions and matrix assembly.The protein is found in various tissues and many of its tyrosineresidues are sulphated. Dermatopontin is postulated to modify thebehavior of TGF-beta through interaction with decorin. [provided byRefSeq].
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Li, X., et al. Biochemistry Mosc. 74(9):979-985(2009)Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)Pochampally, R.R., et al. J. Bone Miner. Res. 22(9):1338-1349(2007)Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :
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