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DPT Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q07507
Clone Names 81006099
Peptide ID 81006099
Additional Information
Gene ID 1805
Other Names Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DPT
Function Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts
Research Areas
Citations (0)

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Background

Dermatopontin is an extracellular matrix protein withpossible functions in cell-matrix interactions and matrix assembly.The protein is found in various tissues and many of its tyrosineresidues are sulphated. Dermatopontin is postulated to modify thebehavior of TGF-beta through interaction with decorin. [provided byRefSeq].

References

Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Li, X., et al. Biochemistry Mosc. 74(9):979-985(2009)Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)Pochampally, R.R., et al. J. Bone Miner. Res. 22(9):1338-1349(2007)Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :

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$ 80.00
Cat# BP12641a
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