GLRX2 Antibody (C-term C153) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NS18 |
---|---|
Clone Names | 81020123 |
Gene ID | 51022 |
---|---|
Other Names | Glutaredoxin-2, mitochondrial, GLRX2, GRX2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GLRX2 |
---|---|
Synonyms | GRX2 |
Function | Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. |
Cellular Location | [Isoform 1]: Mitochondrion. |
Tissue Location | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Glutaredoxins (e.g., GLRX; MIM 600443) are a family ofglutathione-dependent hydrogen donors that participate in a varietyof cellular redox reactions.
References
Wu, H., et al. Biochim. Biophys. Acta 1797(10):1705-1715(2010)Mitra, S., et al. Biochemistry 48(18):3813-3815(2009)Gallogly, M.M., et al. Biochemistry 47(42):11144-11157(2008)Nagy, N., et al. J. Mol. Cell. Cardiol. 44(2):252-260(2008)Karunakaran, S., et al. Brain Res. 1185, 8-17 (2007) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.