|Other Names||Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase B, CAB, Carbonic anhydrase I, CA-I, CA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.|
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Provided below are standard protocols that you may find useful for product applications.
Carbonic anhydrases (CAs) are a large family of zincmetalloenzymes that catalyze the reversible hydration of carbondioxide. They participate in a variety of biological processes,including respiration, calcification, acid-base balance, boneresorption, and the formation of aqueous humor, cerebrospinalfluid, saliva, and gastric acid. They show extensive diversity intissue distribution and in their subcellular localization. CA1 isclosely linked to CA2 and CA3 genes on chromosome 8, and it encodesa cytosolic protein which is found at the highest level inerythrocytes. Variants of this gene have been described in somepopulations. Multiple alternatively spliced variants, encoding thesame protein, have been identified. Transcript variants of CA1utilizing alternative polyA_sites have been described inliterature.
Abhary, S., et al. Mol. Vis. 15, 1179-1184 (2009) :Gambhir, K.K., et al. Biochem. Genet. 45 (5-6), 431-439 (2007) :Temperini, C., et al. Bioorg. Med. Chem. Lett. 17(8):2210-2215(2007)Temperini, C., et al. Bioorg. Med. Chem. Lett. 16(19):5152-5156(2006)Dawson, S.J., et al. J. Infect. 24(3):317-320(1992)
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