|Other Names||Myoblast determination protein 1, Class C basic helix-loop-helix protein 1, bHLHc1, Myogenic factor 3, Myf-3, MYOD1, BHLHC1, MYF3, MYOD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHC1, MYF3, MYOD|
|Function||Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).|
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This gene encodes a nuclear protein that belongs to thebasic helix-loop-helix family of transcription factors and themyogenic factors subfamily. It regulates muscle celldifferentiation by inducing cell cycle arrest, a prerequisite formyogenic initiation. The protein is also involved in muscleregeneration. It activates its own transcription which maystabilize commitment to myogenesis.
Xynos, A., et al. Stem Cells 28(5):965-973(2010)Stuelsatz, P., et al. J. Biol. Chem. 285(17):12670-12683(2010)Hiraoka, S., et al. Hum. Pathol. 41(1):38-47(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Yang, Z., et al. Genes Dev. 23(6):694-707(2009)
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