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FGL1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q08830 |
|---|---|
| Clone Names | 80808102 |
| Gene ID | 2267 |
|---|---|
| Other Names | Fibrinogen-like protein 1, HP-041, Hepassocin, Hepatocyte-derived fibrinogen-related protein 1, HFREP-1, Liver fibrinogen-related protein 1, LFIRE-1, FGL1, HFREP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FGL1 {ECO:0000303|PubMed:18039467, ECO:0000312|HGNC:HGNC:3695} |
|---|---|
| Function | Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). |
| Cellular Location | Secreted. Note=Secreted in the blood plasma |
| Tissue Location | Under normal conditions, liver-specific. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Fibrinogen-like 1 is a member of the fibrinogen family.This protein is homologous to the carboxy terminus of thefibrinogen beta- and gamma- subunits which contains the fourconserved cysteines of fibrinogens and fibrinogen related proteins.However, this protein lacks the platelet-binding site,cross-linking region and a thrombin-sensitive site which arenecessary for fibrin clot formation. This protein may play a rolein the development of hepatocellular carcinomas. Four alternativelyspliced transcript variants encoding the same protein exist forthis gene.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Yu, H.T., et al. J. Biol. Chem. 284(20):13335-13347(2009)
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