|Other Names||Fibrinogen-like protein 1, HP-041, Hepassocin, Hepatocyte-derived fibrinogen-related protein 1, HFREP-1, Liver fibrinogen-related protein 1, LFIRE-1, FGL1, HFREP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has hepatocyte mitogenic activity.|
|Tissue Location||Liver specific.|
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Provided below are standard protocols that you may find useful for product applications.
Fibrinogen-like 1 is a member of the fibrinogen family.This protein is homologous to the carboxy terminus of thefibrinogen beta- and gamma- subunits which contains the fourconserved cysteines of fibrinogens and fibrinogen related proteins.However, this protein lacks the platelet-binding site,cross-linking region and a thrombin-sensitive site which arenecessary for fibrin clot formation. This protein may play a rolein the development of hepatocellular carcinomas. Four alternativelyspliced transcript variants encoding the same protein exist forthis gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Yu, H.T., et al. J. Biol. Chem. 284(20):13335-13347(2009)
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